6GFE

High-resolution Structure of a therapeutic full-length anti-NPRA Antibody with exceptional Conformational Diversity

6GFE の概要

• エントリーDOI: 10.2210/pdb6gfe/pdb
• 分子名称: Immunoglobulin gamma-4 heavy chain, Immunoglobulin gamma-4 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: immunoglobulin, antibody, natriuretic peptide receptor a, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 149267.04

構造登録者

Hoerer, S. (登録日: 2018-04-30, 公開日: 2019-05-15, 最終更新日: 2020-07-29)

• 主引用文献: Blech, M.,Horer, S.,Kuhn, A.B.,Kube, S.,Goddeke, H.,Kiefer, H.,Zang, Y.,Alber, Y.,Kast, S.M.,Westermann, M.,Tully, M.D.,Schafer, L.V.,Garidel, P.; Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity.; Biophys.J., 116:1637-1649, 2019; PubMed: 31023536; DOI: 10.1016/j.bpj.2019.03.036

実験手法

X-RAY DIFFRACTION (1.8 Å)