6GEV

Mineralocorticoid receptor in complex with (s)-13

Summary for 6GEV

• Entry DOI: 10.2210/pdb6gev/pdb
• Descriptor: Mineralocorticoid receptor, Nuclear receptor coactivator 1, GLYCEROL, ... (5 entities in total)
• Functional Keywords: mineralocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 37219.39

Authors

Edman, K.,Aagaard, A.,Tangefjord, S. (deposition date: 2018-04-27, release date: 2019-01-09, Last modification date: 2019-04-24)

• Primary citation: Granberg, K.L.,Yuan, Z.Q.,Lindmark, B.,Edman, K.,Kajanus, J.,Hogner, A.,Malmgren, M.,O'Mahony, G.,Nordqvist, A.,Lindberg, J.,Tangefjord, S.,Kossenjans, M.,Lofberg, C.,Branalt, J.,Liu, D.,Selmi, N.,Nikitidis, G.,Nordberg, P.,Hayen, A.,Aagaard, A.,Hansson, E.,Hermansson, M.,Ivarsson, I.,Jansson-Lofmark, R.,Karlsson, U.,Johansson, U.,William-Olsson, L.,Hartleib-Geschwindner, J.,Bamberg, K.; Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.; J.Med.Chem., 62:1385-1406, 2019; PubMed: 30596500; DOI: 10.1021/acs.jmedchem.8b01523

Experimental method

X-RAY DIFFRACTION (1.54 Å)