6G8N
Yeast 20S proteasome in complex with Cystargolide B Derivative 2
Summary for 6G8N
Entry DOI | 10.2210/pdb6g8n/pdb |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total) |
Functional Keywords | proteasome, inhibitor, beta lactone; natural product derivative, binding analysis, hydrolase |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More |
Total number of polymer chains | 28 |
Total formula weight | 734187.58 |
Authors | Groll, M.,Tello-Aburto, R. (deposition date: 2018-04-09, release date: 2018-09-12, Last modification date: 2024-01-17) |
Primary citation | Niroula, D.,Hallada, L.P.,Le Chapelain, C.,Ganegamage, S.K.,Dotson, D.,Rogelj, S.,Groll, M.,Tello-Aburto, R. Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors. Eur J Med Chem, 157:962-977, 2018 Cited by PubMed: 30165344DOI: 10.1016/j.ejmech.2018.08.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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