6G83
Crystal structure of M. tuberculosis DprE1 in complex with sPBTZ169 (sulfonylPBTZ)
Summary for 6G83
| Entry DOI | 10.2210/pdb6g83/pdb |
| Related | 4NCR |
| Descriptor | Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, [2-(4-cyclohexylsulfonylpiperazin-1-yl)-4-oxidanylidene-6-(trifluoromethyl)-1,3-benzothiazin-8-yl]-oxidanylidene-azanium, ... (4 entities in total) |
| Functional Keywords | dpre1, m. tuberculosis, inhibitor, complex, btz, oxidoreductase |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 2 |
| Total formula weight | 107336.82 |
| Authors | Piton, J.,Makarov, V.,Cole, S.T. (deposition date: 2018-04-07, release date: 2018-08-01, Last modification date: 2024-02-07) |
| Primary citation | Piton, J.,Vocat, A.,Lupien, A.,Foo, C.S.,Riabova, O.,Makarov, V.,Cole, S.T. Structure-Based Drug Design and Characterization of Sulfonyl-Piperazine Benzothiazinone Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 30012754DOI: 10.1128/AAC.00681-18 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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