6G78

RSK4 N-terminal Kinase Domain S232E in complex with AMP-PNP

Summary for 6G78

• Entry DOI: 10.2210/pdb6g78/pdb
• Descriptor: Ribosomal protein S6 kinase alpha-6, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: rsk4, agc kinase, p90 ribosomal s6 kinases, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71558.20

Authors

Prischi, F.,Ali, M.M. (deposition date: 2018-04-04, release date: 2019-04-17, Last modification date: 2024-01-17)

• Primary citation: Chrysostomou, S.,Roy, R.,Prischi, F.,Thamlikitkul, L.,Chapman, K.L.,Mufti, U.,Peach, R.,Ding, L.,Hancock, D.,Moore, C.,Molina-Arcas, M.,Mauri, F.,Pinato, D.J.,Abrahams, J.M.,Ottaviani, S.,Castellano, L.,Giamas, G.,Pascoe, J.,Moonamale, D.,Pirrie, S.,Gaunt, C.,Billingham, L.,Steven, N.M.,Cullen, M.,Hrouda, D.,Winkler, M.,Post, J.,Cohen, P.,Salpeter, S.J.,Bar, V.,Zundelevich, A.,Golan, S.,Leibovici, D.,Lara, R.,Klug, D.R.,Yaliraki, S.N.,Barahona, M.,Wang, Y.,Downward, J.,Skehel, J.M.,Ali, M.M.U.,Seckl, M.J.,Pardo, O.E.; Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.; Sci Transl Med, 13:-, 2021; PubMed: 34261798; DOI: 10.1126/scitranslmed.aba4627

Experimental method

X-RAY DIFFRACTION (2.5 Å)