6G6W
HUMAN PI3KDELTA IN COMPLEX WITH LIGAND LASW1976
Summary for 6G6W
Entry DOI | 10.2210/pdb6g6w/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, ~{N}-[3-[4-[[(1~{S})-1-(5-methyl-4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7~{H}-pyrrolo[ 2,3-d]pyrimidin-5-yl]-5-oxidanyl-phenyl]methanesulfonamide, ... (4 entities in total) |
Functional Keywords | pi3kdelta kinase, proteros biostructures gmbh, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 144591.98 |
Authors | Segarra, V.,Hernandez, B.,Jestel, A.,Mortel, M.,Nagel, S. (deposition date: 2018-04-03, release date: 2018-11-07, Last modification date: 2024-01-17) |
Primary citation | Erra, M.,Taltavull, J.,Bernal, F.J.,Caturla, J.F.,Carrascal, M.,Pages, L.,Mir, M.,Espinosa, S.,Gracia, J.,Dominguez, M.,Sabate, M.,Paris, S.,Maldonado, M.,Hernandez, B.,Bravo, M.,Calama, E.,Miralpeix, M.,Lehner, M.D.,Calbet, M. Discovery of a Novel Inhaled PI3K delta Inhibitor for the Treatment of Respiratory Diseases. J. Med. Chem., 61:9551-9567, 2018 Cited by PubMed: 30351000DOI: 10.1021/acs.jmedchem.8b00873 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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