6G5K
Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1
This is a non-PDB format compatible entry.
Summary for 6G5K
Entry DOI | 10.2210/pdb6g5k/pdb |
Descriptor | Botulinum neurotoxin type B, Synaptotagmin-1 (3 entities in total) |
Functional Keywords | botulinum toxin, neurotoxin, protein engineering, receptor binding, toxin |
Biological source | Clostridium botulinum More |
Total number of polymer chains | 4 |
Total formula weight | 115257.75 |
Authors | Masuyer, G.,Elliot, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Beard, M.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Dong, M.,Krupp, J.,Stenmark, P. (deposition date: 2018-03-29, release date: 2019-01-16, Last modification date: 2024-01-31) |
Primary citation | Elliott, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Masuyer, G.,Beard, M.,Boone, C.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Zhang, S.,Dong, M.,Stenmark, P.,Krupp, J. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv, 5:eaau7196-eaau7196, 2019 Cited by PubMed: 30746458DOI: 10.1126/sciadv.aau7196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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