6G5K

Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Botulinum neurotoxin type B	polymer	461	55157.1	2	UniProt (P10844)	Clostridium botulinum	BoNT/B,Bontoxilysin-B
2	B, D (C, 33)	Synaptotagmin-1	polymer	21	2471.8	2	UniProt (P21579)	Homo sapiens	Synaptotagmin I,SytI,p65
3	E, F, G, H (A, C, B, 33)	water	water		18.0	439	Chemie (HOH)

Sequence modifications

A, B: 857 - 1291 (UniProt: P10844)

PDB	External Database	Details
Met 833	-	initiating methionine
Gly 834	-	expression tag
Ser 835	-	expression tag
Ser 836	-	expression tag
His 837	-	expression tag
His 838	-	expression tag
His 839	-	expression tag
His 840	-	expression tag
His 841	-	expression tag
His 842	-	expression tag
Ser 843	-	expression tag
Ser 844	-	expression tag
Gly 845	-	expression tag
Leu 846	-	expression tag
Val 847	-	expression tag
Pro 848	-	expression tag
Arg 849	-	expression tag
Gly 850	-	expression tag
Ser 851	-	expression tag
His 852	-	expression tag
Met 853	-	expression tag
Ala 854	-	expression tag
Ser 855	-	expression tag
Met 856	-	expression tag
Leu 1292	-	expression tag
Gln 1293	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	115257.8
All*	Total formula weight	115257.8

*Water molecules are not included.