6G5F
Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1
Summary for 6G5F
Entry DOI | 10.2210/pdb6g5f/pdb |
Descriptor | Botulinum neurotoxin type B, Synaptotagmin-1, GLYCEROL, ... (5 entities in total) |
Functional Keywords | botulinum toxin, neurotoxin, protein engineering, receptor binding, toxin |
Biological source | Clostridium botulinum More |
Total number of polymer chains | 3 |
Total formula weight | 304983.75 |
Authors | Masuyer, G.,Elliot, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Beard, M.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Dong, M.,Krupp, J.,Stenmark, P. (deposition date: 2018-03-29, release date: 2019-01-16, Last modification date: 2024-01-31) |
Primary citation | Elliott, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Masuyer, G.,Beard, M.,Boone, C.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Zhang, S.,Dong, M.,Stenmark, P.,Krupp, J. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv, 5:eaau7196-eaau7196, 2019 Cited by PubMed: 30746458DOI: 10.1126/sciadv.aau7196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report