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6G5F

Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BBotulinum neurotoxin type Bpolymer1291151066.82UniProt (P10844)
Pfam (PF01742)
Pfam (PF07952)
Pfam (PF07953)
Pfam (PF07951)
In PDB
Clostridium botulinumBoNT/B,Bontoxilysin-B
2PSynaptotagmin-1polymer212471.81UniProt (P21579)
In PDB
Homo sapiensSynaptotagmin I,SytI,p65
3AGLYCEROLnon-polymer92.13Chemie (GOL)
4BMALONATE IONnon-polymer102.01Chemie (MLI)
5waterwater18.0268Chemie (HOH)
Sequence modifications
A, B: 1 - 1291 (UniProt: P10844)
PDBExternal DatabaseDetails
Gln 231Glu 231engineered mutation
Tyr 234His 234engineered mutation
Met 1191Glu 1191engineered mutation
Tyr 1199Ser 1199engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight304605.4
Non-Polymers*Number of molecules4
Total formula weight378.3
All*Total formula weight304983.7
*Water molecules are not included.

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PDB entries from 2024-03-27

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