6G5F

Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1

Descriptor	Botulinum neurotoxin type B, Synaptotagmin-1, GLYCEROL, ... (5 entities in total)
Functional Keywords	botulinum toxin, neurotoxin, protein engineering, receptor binding, toxin
Biological source	Clostridium botulinum More
Total number of polymer chains	3
Total molecular weight	304983.75
Authors	Masuyer, G.,Elliot, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Beard, M.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Dong, M.,Krupp, J.,Stenmark, P. (deposition date: 2018-03-29, release date: 2019-01-16)
Primary citation	Elliot, M.,Favre-Guilmard, C.,Liu, S.M.,Maignel, J.,Masuyer, G.,Beard, M.,Carre, D.,Kalinichev, M.,Lezmi, S.,Mir, I.,Nicoleau, C.,Palan, S.,Perier, C.,Raban, E.,Dong, M.,Stenmark, P.,Krupp, J. Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models Sci Adv, 2019
Experimental method	X-RAY DIFFRACTION (2.5 Å)