6G22

Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PEU

Summary for 6G22

Entry DOI	10.2210/pdb6g22/pdb
Related	6G2L 6G2M 6G2N
Descriptor	5'(3')-deoxyribonucleotidase, mitochondrial, MAGNESIUM ION, BETA-MERCAPTOETHANOL, ... (6 entities in total)
Functional Keywords	5'-nucleotidase, dephosphorylation, phosphorylation, had-like, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	24060.47
Authors	Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2018-03-22, release date: 2018-07-11, Last modification date: 2024-01-17)
Primary citation	Pachl, P.,Simak, O.,Budesinsky, M.,Brynda, J.,Rosenberg, I.,Rezacova, P. Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases Eur.J.Org.Chem., 2018 Cited by DOI: 10.1002/ejoc.201800515 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation