6G22
Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PEU
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'(3')-deoxyribonucleotidase, mitochondrial | polymer | 202 | 23271.5 | 1 | UniProt (Q9NPB1) Pfam (PF06941) | Homo sapiens (Human) | 5',3'-nucleotidase,mitochondrial,Deoxy-5'-nucleotidase 2,dNT-2 |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (A) | 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione | non-polymer | 502.3 | 1 | Chemie (2O2) | |||
| 6 | G (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 32 - 228 (UniProt: Q9NPB1)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | - | expression tag |
| Asn 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Ser 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23271.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 788.9 | |
| All* | Total formula weight | 24060.5 |
