6G1E
BEAT Fc with improved heterodimerization (Q3A-D84.4Q)
6G1E の概要
エントリーDOI | 10.2210/pdb6g1e/pdb |
関連するPDBエントリー | 5M3V |
分子名称 | Immunoglobulin heavy constant gamma 1,Immunoglobulin heavy constant gamma 3, Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
機能のキーワード | antibody, tcr, bispecific, heterodimer, immune system |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 55058.53 |
構造登録者 | |
主引用文献 | Stutz, C.,Blein, S. A single mutation increases heavy chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species. J.Biol.Chem., 2020 Cited by PubMed: 32404368DOI: 10.1074/jbc.RA119.012335 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.88 Å) |
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