6G0W

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72

Summary for 6G0W

• Entry DOI: 10.2210/pdb6g0w/pdb
• Descriptor: Poly [ADP-ribose] polymerase 14, 4-[3-[4-(4-fluorophenyl)piperidin-1-yl]carbonylphenoxy]benzamide (3 entities in total)
• Functional Keywords: adp-ribosylation, inhibitor complex, transferase domain, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q460N5
• Total number of polymer chains: 2
• Total formula weight: 45074.10

Authors

Karlberg, T.,Thorsell, A.G.,Holechek, J.,Lease, R.,Ferraris, D.,Schuler, H. (deposition date: 2018-03-20, release date: 2018-05-23, Last modification date: 2024-01-17)

• Primary citation: Holechek, J.,Lease, R.,Thorsell, A.G.,Karlberg, T.,McCadden, C.,Grant, R.,Keen, A.,Callahan, E.,Schuler, H.,Ferraris, D.; Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.; Bioorg. Med. Chem. Lett., 28:2050-2054, 2018; PubMed: 29748053; DOI: 10.1016/j.bmcl.2018.04.056

Experimental method

X-RAY DIFFRACTION (2.34 Å)