6FZ5

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

Summary for 6FZ5

• Entry DOI: 10.2210/pdb6fz5/pdb
• Related: 3IU1 3IU2 3IWE 4C2Z 6FZ2 6FZ3
• Descriptor: Glycylpeptide N-tetradecanoyltransferase 1, 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, TETRADECANOYL-COA, ... (6 entities in total)
• Functional Keywords: protein-ligand complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 92370.34

Authors

Kersten, F.C.,Brenk, R. (deposition date: 2018-03-14, release date: 2019-03-27, Last modification date: 2024-05-08)

• Primary citation: Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R.; How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System.; J.Med.Chem., 63:2095-2113, 2020; PubMed: 31423787; DOI: 10.1021/acs.jmedchem.9b00586

Experimental method

X-RAY DIFFRACTION (1.89 Å)