6FZ5

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

6FZ5 の概要

• エントリーDOI: 10.2210/pdb6fz5/pdb
• 関連するPDBエントリー: 3IU1 3IU2 3IWE 4C2Z 6FZ2 6FZ3
• 分子名称: Glycylpeptide N-tetradecanoyltransferase 1, 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, TETRADECANOYL-COA, ... (6 entities in total)
• 機能のキーワード: protein-ligand complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92370.34

構造登録者

Kersten, F.C.,Brenk, R. (登録日: 2018-03-14, 公開日: 2019-03-27, 最終更新日: 2024-05-08)

• 主引用文献: Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R.; How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System.; J.Med.Chem., 63:2095-2113, 2020; PubMed: 31423787; DOI: 10.1021/acs.jmedchem.9b00586

実験手法

X-RAY DIFFRACTION (1.89 Å)