6FZ4

Structure of GluK1 ligand-binding domain in complex with N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide at 1.85 A resolution

Summary for 6FZ4

Entry DOI	10.2210/pdb6fz4/pdb
Descriptor	Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, GLYCEROL, SULFATE ION, ... (6 entities in total)
Functional Keywords	kainate receptor ligand-binding domain, gluk1-s1s2, membrane protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	1
Total formula weight	30083.69
Authors	Kastrup, J.S.,Frydenvang, K.,Mollerud, S. (deposition date: 2018-03-14, release date: 2019-01-23, Last modification date: 2024-01-17)
Primary citation	Pallesen, J.,Mollerud, S.,Frydenvang, K.,Pickering, D.S.,Bornholdt, J.,Nielsen, B.,Pasini, D.,Han, L.,Marconi, L.,Kastrup, J.S.,Johansen, T.N. N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology. Acs Chem Neurosci, 10:1841-1853, 2019 Cited by PubMed: 30620174 DOI: 10.1021/acschemneuro.8b00726 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation