6FZ4

Structure of GluK1 ligand-binding domain in complex with N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide at 1.85 A resolution

6FZ4 の概要

• エントリーDOI: 10.2210/pdb6fz4/pdb
• 分子名称: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, GLYCEROL, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: kainate receptor ligand-binding domain, gluk1-s1s2, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30083.69

構造登録者

Kastrup, J.S.,Frydenvang, K.,Mollerud, S. (登録日: 2018-03-14, 公開日: 2019-01-23, 最終更新日: 2024-01-17)

• 主引用文献: Pallesen, J.,Mollerud, S.,Frydenvang, K.,Pickering, D.S.,Bornholdt, J.,Nielsen, B.,Pasini, D.,Han, L.,Marconi, L.,Kastrup, J.S.,Johansen, T.N.; N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology.; Acs Chem Neurosci, 10:1841-1853, 2019; PubMed: 30620174; DOI: 10.1021/acschemneuro.8b00726

実験手法

X-RAY DIFFRACTION (1.85 Å)