6FWK

The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide

6FWK の概要

• エントリーDOI: 10.2210/pdb6fwk/pdb
• 分子名称: DNA polymerase epsilon catalytic subunit A, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), ... (7 entities in total)
• 機能のキーワード: pol epsilon, m644g, dna, complex, dna binding protein
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 291283.69

構造登録者

Parkash, V.,Johansson, E. (登録日: 2018-03-06, 公開日: 2019-01-30, 最終更新日: 2024-05-08)

• 主引用文献: Parkash, V.,Kulkarni, Y.,Ter Beek, J.,Shcherbakova, P.V.,Kamerlin, S.C.L.,Johansson, E.; Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.; Nat Commun, 10:373-373, 2019; PubMed: 30670696; DOI: 10.1038/s41467-018-08114-9

実験手法

X-RAY DIFFRACTION (2.503 Å)