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6FVZ

Crystal structure of human monoamine oxidase B (MAO B) in complex with dimethylphenyl-chromone-carboxamide

Summary for 6FVZ
Entry DOI10.2210/pdb6fvz/pdb
DescriptorAmine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-(3,4-dimethylphenyl)-4-oxidanylidene-chromene-3-carboxamide, ... (6 entities in total)
Functional Keywordsparkinson's disease, drug design, chromone, inhibitor, flavoprotein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight120690.49
Authors
Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. (deposition date: 2018-03-05, release date: 2018-04-25, Last modification date: 2024-01-17)
Primary citationReis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C.
Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.
J. Med. Chem., 61:4203-4212, 2018
Cited by
PubMed: 29648817
DOI: 10.1021/acs.jmedchem.8b00357
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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