6FTZ
COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 6
Summary for 6FTZ
Entry DOI | 10.2210/pdb6ftz/pdb |
Descriptor | Complement factor D, ~{N}4-[3-(aminomethyl)phenyl]-1~{H}-indole-2,4-dicarboxamide (3 entities in total) |
Functional Keywords | serine protease, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 25047.46 |
Authors | Ostermann, N. (deposition date: 2018-02-26, release date: 2018-06-06, Last modification date: 2024-01-17) |
Primary citation | Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J. Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9:490-495, 2018 Cited by PubMed: 29795765DOI: 10.1021/acsmedchemlett.8b00104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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