6FT7
Crystal structure of CLK3 in complex with compound 8a
Summary for 6FT7
| Entry DOI | 10.2210/pdb6ft7/pdb |
| Descriptor | Dual specificity protein kinase CLK3, IODIDE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
| Functional Keywords | kinase, inhibitor, splicing kinase, clk, structural genomics, structural genomics consortium, sgc, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49761 |
| Total number of polymer chains | 2 |
| Total formula weight | 87650.83 |
| Authors | Chaikuad, A.,Walter, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-20, release date: 2018-05-16, Last modification date: 2024-01-17) |
| Primary citation | Walter, A.,Chaikuad, A.,Helmer, R.,Loaec, N.,Preu, L.,Ott, I.,Knapp, S.,Meijer, L.,Kunick, C. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS ONE, 13:e0196761-e0196761, 2018 Cited by PubMed: 29723265DOI: 10.1371/journal.pone.0196761 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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