6FR0
Crystal structure of CREBBP bromodomain complexd with PB08
Summary for 6FR0
| Entry DOI | 10.2210/pdb6fr0/pdb |
| Descriptor | CREB-binding protein, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(2-ethyl-5-methyl-3-oxidanylidene-1,2-oxazol-4-yl)phenyl]furan-2-carboxamide (3 entities in total) |
| Functional Keywords | inhibitor, bromodomain, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 29395.71 |
| Authors | Zhu, J.,Caflisch, A. (deposition date: 2018-02-15, release date: 2018-08-29, Last modification date: 2024-01-17) |
| Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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