6FQM
3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA
Summary for 6FQM
Entry DOI | 10.2210/pdb6fqm/pdb |
Related | 5cdq |
Descriptor | DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*T)-3'), ... (9 entities in total) |
Functional Keywords | type iia topoisomerase, antibacterial, inhibitor, isomerase |
Biological source | Staphylococcus aureus subsp. aureus N315 More |
Cellular location | Cytoplasm : P66937 Q99XG5 P66937 |
Total number of polymer chains | 12 |
Total formula weight | 339562.41 |
Authors | Bax, B.D.,Germe, T.,Basque, E.,Maxwell, A. (deposition date: 2018-02-14, release date: 2018-04-04, Last modification date: 2024-01-17) |
Primary citation | Germe, T.,Voros, J.,Jeannot, F.,Taillier, T.,Stavenger, R.A.,Bacque, E.,Maxwell, A.,Bax, B.D. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46:4114-4128, 2018 Cited by PubMed: 29538767DOI: 10.1093/nar/gky181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.06 Å) |
Structure validation
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