6FP0
The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 4
Summary for 6FP0
Entry DOI | 10.2210/pdb6fp0/pdb |
Descriptor | Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, (2~{R})-2-[[(2~{R})-5-chloranyl-1-methyl-2,3-dihydroindol-2-yl]carbonylamino]-2-cyclohexyl-ethanoic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, oxidoreductase |
Biological source | Pseudomonas fluorescens |
Total number of polymer chains | 2 |
Total formula weight | 103244.71 |
Authors | Levy, C.W.,Leys, D. (deposition date: 2018-02-08, release date: 2019-08-21, Last modification date: 2024-05-01) |
Primary citation | Zhang, S.,Sakuma, M.,Deora, G.S.,Levy, C.W.,Klausing, A.,Breda, C.,Read, K.D.,Edlin, C.D.,Ross, B.P.,Wright Muelas, M.,Day, P.J.,O'Hagan, S.,Kell, D.B.,Schwarcz, R.,Leys, D.,Heyes, D.J.,Giorgini, F.,Scrutton, N.S. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol, 2:271-271, 2019 Cited by PubMed: 31372510DOI: 10.1038/s42003-019-0520-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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