6FP0

The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 4

Summary for 6FP0

• Entry DOI: 10.2210/pdb6fp0/pdb
• Descriptor: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, (2~{R})-2-[[(2~{R})-5-chloranyl-1-methyl-2,3-dihydroindol-2-yl]carbonylamino]-2-cyclohexyl-ethanoic acid, ... (5 entities in total)
• Functional Keywords: inhibitor, oxidoreductase
• Biological source: Pseudomonas fluorescens
• Total number of polymer chains: 2
• Total formula weight: 103244.71

Authors

Levy, C.W.,Leys, D. (deposition date: 2018-02-08, release date: 2019-08-21, Last modification date: 2020-03-04)

• Primary citation: Zhang, S.,Sakuma, M.,Deora, G.S.,Levy, C.W.,Klausing, A.,Breda, C.,Read, K.D.,Edlin, C.D.,Ross, B.P.,Wright Muelas, M.,Day, P.J.,O'Hagan, S.,Kell, D.B.,Schwarcz, R.,Leys, D.,Heyes, D.J.,Giorgini, F.,Scrutton, N.S.; A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.; Commun Biol, 2:271-271, 2019; PubMed: 31372510; DOI: 10.1038/s42003-019-0520-5

Experimental method

X-RAY DIFFRACTION (2.03 Å)