6FO6

CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911

Summary for 6FO6

• Entry DOI: 10.2210/pdb6fo6/pdb
• EMDB information: 4286 4288 4292
• Descriptor: Cytochrome b-c1 complex subunit Rieske, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol, ... (12 entities in total)
• Functional Keywords: cryo-em, inhibitor binding, membrane protein, cytochrome bc1
• Biological source: Bos taurus (Bovine); More
• Total number of polymer chains: 18
• Total formula weight: 504353.27

Authors

Johnson, R.M.,Amporndanai, K.,O'Neill, P.M.,Fishwick, C.W.G.,Jamson, A.H.,Rawson, S.D.,Hasnain, S.S.,Antonyuk, S.V.,Muench, S.P. (deposition date: 2018-02-06, release date: 2018-02-28, Last modification date: 2019-12-11)

• Primary citation: Amporndanai, K.,Johnson, R.M.,O'Neill, P.M.,Fishwick, C.W.G.,Jamson, A.H.,Rawson, S.,Muench, S.P.,Hasnain, S.S.,Antonyuk, S.V.; X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.; IUCrJ, 5:200-210, 2018; PubMed: 29765610; DOI: 10.1107/S2052252518001616

Experimental method

ELECTRON MICROSCOPY (4.1 Å)