6FO6

CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911

6FO6 の概要

• エントリーDOI: 10.2210/pdb6fo6/pdb
• EMDBエントリー: 4286 4288 4292
• 分子名称: Cytochrome b-c1 complex subunit Rieske, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol, ... (12 entities in total)
• 機能のキーワード: cryo-em, inhibitor binding, membrane protein, cytochrome bc1
• 由来する生物種: Bos taurus (Bovine); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 504353.27

構造登録者

Johnson, R.M.,Amporndanai, K.,O'Neill, P.M.,Fishwick, C.W.G.,Jamson, A.H.,Rawson, S.D.,Hasnain, S.S.,Antonyuk, S.V.,Muench, S.P. (登録日: 2018-02-06, 公開日: 2018-02-28, 最終更新日: 2019-12-11)

• 主引用文献: Amporndanai, K.,Johnson, R.M.,O'Neill, P.M.,Fishwick, C.W.G.,Jamson, A.H.,Rawson, S.,Muench, S.P.,Hasnain, S.S.,Antonyuk, S.V.; X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.; IUCrJ, 5:200-210, 2018; PubMed: 29765610; DOI: 10.1107/S2052252518001616

実験手法

ELECTRON MICROSCOPY (4.1 Å)