6FNU

Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain

Summary for 6FNU

Entry DOI	10.2210/pdb6fnu/pdb
Descriptor	Methylenetetrahydrofolate reductase 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	reductase, one carbon metabolism, tim barrel, folate metabolism, structural genomics, structural genomics consortium, sgc, oxidoreductase
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Total number of polymer chains	1
Total formula weight	35580.30
Authors	Kopec, J.,Rembeza, E.,Bezerra, G.A.,Newman, J.,Bountra, C.,Froese, D.S.,Baumgartner, M.,Yue, W.W.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-05, release date: 2018-03-07, Last modification date: 2018-07-04)
Primary citation	Froese, D.S.,Kopec, J.,Rembeza, E.,Bezerra, G.A.,Oberholzer, A.E.,Suormala, T.,Lutz, S.,Chalk, R.,Borkowska, O.,Baumgartner, M.R.,Yue, W.W. Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Nat Commun, 9:2261-2261, 2018 Cited by PubMed: 29891918 DOI: 10.1038/s41467-018-04735-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation