6FNE
Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain
Summary for 6FNE
Entry DOI | 10.2210/pdb6fne/pdb |
Descriptor | IQ motif and SEC7 domain-containing protein 1, (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, NONAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | arf gef, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 95474.78 |
Authors | Nawrotek, A.,Zeghouf, M.,Cherfils, J. (deposition date: 2018-02-03, release date: 2019-03-13, Last modification date: 2024-01-17) |
Primary citation | Nawrotek, A.,Benabdi, S.,Niyomchon, S.,Kryszke, M.H.,Ginestier, C.,Caneque, T.,Tepshi, L.,Mariani, A.,St Onge, R.P.,Giaever, G.,Nislow, C.,Charafe-Jauffret, E.,Rodriguez, R.,Zeghouf, M.,Cherfils, J. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat.Chem.Biol., 15:358-366, 2019 Cited by PubMed: 30742123DOI: 10.1038/s41589-019-0228-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.501 Å) |
Structure validation
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