6FMK

pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4)

Summary for 6FMK

Entry DOI	10.2210/pdb6fmk/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	protein complex, ubiquitin ligase, hypoxia inducible factor, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	164526.71
Authors	Soares, P.,Lucas, X.,Ciulli, A. (deposition date: 2018-01-31, release date: 2018-04-11, Last modification date: 2018-06-20)
Primary citation	Soares, P.,Lucas, X.,Ciulli, A. Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26:2992-2995, 2018 Cited by PubMed: 29650462 DOI: 10.1016/j.bmc.2018.03.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation