6FMD

Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold

6FMD の概要

• エントリーDOI: 10.2210/pdb6fmd/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide, CHLORIDE ION, ... (9 entities in total)
• 機能のキーワード: dhodh, inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45637.54

構造登録者

Goyal, P.,Jarva, M.,Andersson, M.,Lolli, M.L.,Friemann, R. (登録日: 2018-01-30, 公開日: 2018-07-11, 最終更新日: 2024-01-17)

• 主引用文献: Sainas, S.,Pippione, A.C.,Lupino, E.,Giorgis, M.,Circosta, P.,Gaidano, V.,Goyal, P.,Bonanni, D.,Rolando, B.,Cignetti, A.,Ducime, A.,Andersson, M.,Jarva, M.,Friemann, R.,Piccinini, M.,Ramondetti, C.,Buccinna, B.,Al-Karadaghi, S.,Boschi, D.,Saglio, G.,Lolli, M.L.; Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.; J. Med. Chem., 61:6034-6055, 2018; PubMed: 29939742; DOI: 10.1021/acs.jmedchem.8b00373

実験手法

X-RAY DIFFRACTION (1.58 Å)