6FJM

tubulin-Disorazole Z complex

Summary for 6FJM

• Entry DOI: 10.2210/pdb6fjm/pdb
• Related: 6FII 6FJF
• Descriptor: Tubulin alpha-1B chain, Disorazole Z, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 265413.40

Authors

Menchon, G.,Prota, A.E.,Lucena Agell, D.,Bucher, P.,Jansen, R.,Irschik, H.,Mueller, R.,Paterson, I.,Diaz, J.F.,Altmann, K.-H.,Steinmetz, M.O. (deposition date: 2018-01-22, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Menchon, G.,Prota, A.E.,Lucena-Agell, D.,Bucher, P.,Jansen, R.,Irschik, H.,Muller, R.,Paterson, I.,Diaz, J.F.,Altmann, K.H.,Steinmetz, M.O.; A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.; Nat Commun, 9:2106-2106, 2018; PubMed: 29844393; DOI: 10.1038/s41467-018-04535-8

Experimental method

X-RAY DIFFRACTION (2.1 Å)