6FIN

DDR1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1.670A, P1211, Rfree=22.8%

6FIN の概要

• エントリーDOI: 10.2210/pdb6fin/pdb
• 関連するPDBエントリー: 6fer 6few 6fex 6fil 6fim
• 分子名称: Epithelial discoidin domain-containing receptor 1, IODIDE ION, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{H}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, ... (4 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38015.64

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Kuhn, B.,Rudolph, M.G. (登録日: 2018-01-19, 公開日: 2018-11-28, 最終更新日: 2024-05-01)

• 主引用文献: Richter, H.,Satz, A.L.,Bedoucha, M.,Buettelmann, B.,Petersen, A.C.,Harmeier, A.,Hermosilla, R.,Hochstrasser, R.,Burger, D.,Gsell, B.,Gasser, R.,Huber, S.,Hug, M.N.,Kocer, B.,Kuhn, B.,Ritter, M.,Rudolph, M.G.,Weibel, F.,Molina-David, J.,Kim, J.J.,Santos, J.V.,Stihle, M.,Georges, G.J.,Bonfil, R.D.,Fridman, R.,Uhles, S.,Moll, S.,Faul, C.,Fornoni, A.,Prunotto, M.; DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.; Acs Chem.Biol., 14:37-49, 2019; PubMed: 30452219; DOI: 10.1021/acschembio.8b00866

実験手法

X-RAY DIFFRACTION (1.67 Å)