6FIB

Structure of human 4-1BB ligand

6FIB の概要

• エントリーDOI: 10.2210/pdb6fib/pdb
• 分子名称: Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein, ... (4 entities in total)
• 機能のキーワード: cytokine, signal anchor, tnf family
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 82496.89

構造登録者

Joseph, C.,Claus, C.,Ferrara, C.,von Hirschheydt, T.,Prince, C.,Funk, D.,Klein, C.,Benz, J. (登録日: 2018-01-17, 公開日: 2019-03-13, 最終更新日: 2024-01-17)

• 主引用文献: Claus, C.,Ferrara, C.,Xu, W.,Sam, J.,Lang, S.,Uhlenbrock, F.,Albrecht, R.,Herter, S.,Schlenker, R.,Husser, T.,Diggelmann, S.,Challier, J.,Mossner, E.,Hosse, R.J.,Hofer, T.,Brunker, P.,Joseph, C.,Benz, J.,Ringler, P.,Stahlberg, H.,Lauer, M.,Perro, M.,Chen, S.,Kuttel, C.,Bhavani Mohan, P.L.,Nicolini, V.,Birk, M.C.,Ongaro, A.,Prince, C.,Gianotti, R.,Dugan, G.,Whitlow, C.T.,Solingapuram Sai, K.K.,Caudell, D.L.,Burgos-Rodriguez, A.G.,Cline, J.M.,Hettich, M.,Ceppi, M.,Giusti, A.M.,Crameri, F.,Driessen, W.,Morcos, P.N.,Freimoser-Grundschober, A.,Levitsky, V.,Amann, M.,Grau-Richards, S.,von Hirschheydt, T.,Tournaviti, S.,Molhoj, M.,Fauti, T.,Heinzelmann-Schwarz, V.,Teichgraber, V.,Colombetti, S.,Bacac, M.,Zippelius, A.,Klein, C.,Umana, P.; Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.; Sci Transl Med, 11:-, 2019; PubMed: 31189721; DOI: 10.1126/scitranslmed.aav5989

実験手法

X-RAY DIFFRACTION (2.7 Å)