6FGO

Fc in complex with engineered calcium binding domain Z

Summary for 6FGO

Entry DOI	10.2210/pdb6fgo/pdb
Descriptor	Immunoglobulin gamma-1 heavy chain, Z-Ca, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	antibody, protein a, ef-hand, calcium-binding, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	133434.27
Authors	Venskutonyte, R.,Kanje, S.,Hober, S.,Lindkvist-Petersson, K. (deposition date: 2018-01-11, release date: 2018-06-20, Last modification date: 2024-01-17)
Primary citation	Kanje, S.,Venskutonyte, R.,Scheffel, J.,Nilvebrant, J.,Lindkvist-Petersson, K.,Hober, S. Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies. J. Mol. Biol., 430:3427-3438, 2018 Cited by PubMed: 29886013 DOI: 10.1016/j.jmb.2018.06.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation