6FGD

Crystal structure of Gephyrin E domain in complex with Artemether

Summary for 6FGD

DescriptorGephyrin, CALCIUM ION, PHOSPHATE ION, ... (9 entities in total)
Functional Keywordsantimalarial compound, scaffolding protein, moonlighting protein, inhibitory neurotransmission, structural protein
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains1
Total molecular weight48111.32
Authors
Kasaragod, V.B.,Schindelin, H. (deposition date: 2018-01-10, release date: 2019-01-16, Last modification date: 2019-02-13)
Primary citation
Kasaragod, V.B.,Hausrat, T.J.,Schaefer, N.,Kuhn, M.,Christensen, N.R.,Tessmer, I.,Maric, H.M.,Madsen, K.L.,Sotriffer, C.,Villmann, C.,Kneussel, M.,Schindelin, H.
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Neuron, 2019
PubMed: 30704910 (PDB entries with the same primary citation)
DOI: 10.1016/j.neuron.2019.01.001
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20740 0.6% 7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6fgd
no rotation
Molmil generated image of 6fgd
rotated about x axis by 90°
Molmil generated image of 6fgd
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6fgd
no rotation
Molmil generated image of 6fgd
rotated about x axis by 90°
Molmil generated image of 6fgd
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6fgd.pdb1.gz [446.75 KB])
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