6FGA

Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1

Summary for 6FGA

Entry DOI	10.2210/pdb6fga/pdb
Descriptor	E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 E1, ZINC ION, ... (5 entities in total)
Functional Keywords	ring-type e3 ligase, ubc core domain and ubiquitination, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	15
Total formula weight	214164.11
Authors	Anandapadamanaban, M.,Moche, M.,Sunnerhagen, M. (deposition date: 2018-01-10, release date: 2019-06-12, Last modification date: 2019-08-07)
Primary citation	Anandapadamanaban, M.,Kyriakidis, N.C.,Csizmok, V.,Wallenhammar, A.,Espinosa, A.C.,Ahlner, A.,Round, A.R.,Trewhella, J.,Moche, M.,Wahren-Herlenius, M.,Sunnerhagen, M. E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2. J.Biol.Chem., 294:11404-11419, 2019 Cited by PubMed: 31160341 DOI: 10.1074/jbc.RA119.008485 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation