6FFM
Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor
Summary for 6FFM
Entry DOI | 10.2210/pdb6ffm/pdb |
Descriptor | Kelch-like ECH-associated protein 1, ~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide (3 entities in total) |
Functional Keywords | 3-bromo-4 5-dihydroisoxazole, btb domain, antioxidant response, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15410.80 |
Authors | Moniot, S.,Steegborn, C. (deposition date: 2018-01-08, release date: 2018-11-14, Last modification date: 2024-01-17) |
Primary citation | Pinto, A.,El Ali, Z.,Moniot, S.,Tamborini, L.,Steegborn, C.,Foresti, R.,De Micheli, C. Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression. ChemistryOpen, 7:858-864, 2018 Cited by PubMed: 30397576DOI: 10.1002/open.201800185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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