6FFM

Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor

6FFM の概要

• エントリーDOI: 10.2210/pdb6ffm/pdb
• 分子名称: Kelch-like ECH-associated protein 1, ~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide (3 entities in total)
• 機能のキーワード: 3-bromo-4 5-dihydroisoxazole, btb domain, antioxidant response, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15410.80

構造登録者

Moniot, S.,Steegborn, C. (登録日: 2018-01-08, 公開日: 2018-11-14, 最終更新日: 2024-01-17)

• 主引用文献: Pinto, A.,El Ali, Z.,Moniot, S.,Tamborini, L.,Steegborn, C.,Foresti, R.,De Micheli, C.; Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.; ChemistryOpen, 7:858-864, 2018; PubMed: 30397576; DOI: 10.1002/open.201800185

実験手法

X-RAY DIFFRACTION (2.2 Å)