6FFG
Human BRD2 C-terminal bromodomain with (S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethanone
Summary for 6FFG
Entry DOI | 10.2210/pdb6ffg/pdb |
Related | 6FFD 6FFE 6FFF |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, (S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethanone, ... (6 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14381.62 |
Authors | Chung, C. (deposition date: 2018-01-07, release date: 2019-01-30, Last modification date: 2024-05-08) |
Primary citation | Law, R.P.,Atkinson, S.J.,Bamborough, P.,Chung, C.W.,Demont, E.H.,Gordon, L.J.,Lindon, M.,Prinjha, R.K.,Watson, A.J.B.,Hirst, D.J. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain. J.Med.Chem., 61:4317-4334, 2018 Cited by PubMed: 29656650DOI: 10.1021/acs.jmedchem.7b01666 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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