6FFG
Human BRD2 C-terminal bromodomain with (S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethanone
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue EDO A 501 |
Chain | Residue |
A | TYR426 |
A | ARG440 |
A | GLN443 |
A | GLN443 |
A | ASP444 |
A | HOH651 |
A | HOH651 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue EDO A 502 |
Chain | Residue |
A | ASP407 |
A | MET438 |
A | LYS441 |
A | HOH602 |
A | TYR368 |
A | LYS402 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue D7B A 503 |
Chain | Residue |
A | TRP370 |
A | PRO371 |
A | LEU383 |
A | CYS425 |
A | TYR428 |
A | ASN429 |
A | HIS433 |
A | HOH620 |
A | HOH628 |
A | HOH641 |
A | HOH676 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue PEG A 504 |
Chain | Residue |
A | SER347 |
A | LYS351 |
A | MES506 |
A | HOH601 |
A | HOH636 |
A | HOH661 |
A | HOH677 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue PEG A 505 |
Chain | Residue |
A | LYS351 |
A | ASP385 |
A | TYR428 |
A | MES506 |
A | HOH601 |
A | HOH623 |
A | HOH643 |
A | HOH677 |
site_id | AC6 |
Number of Residues | 14 |
Details | binding site for residue MES A 506 |
Chain | Residue |
A | ASN354 |
A | LYS427 |
A | TYR428 |
A | ASN429 |
A | PRO430 |
A | PRO431 |
A | PEG504 |
A | PEG505 |
A | HOH601 |
A | HOH622 |
A | HOH634 |
A | HOH636 |
A | HOH639 |
A | HOH700 |
Functional Information from PROSITE/UniProt
site_id | PS00633 |
Number of Residues | 60 |
Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
Chain | Residue | Details |
A | ALA369-TYR428 | |