6FER

Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide

6FER の概要

• エントリーDOI: 10.2210/pdb6fer/pdb
• 分子名称: Discoidin domain-containing receptor 2, 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide (2 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 435194.03

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Kuhn, B.,Rudolph, M.G. (登録日: 2018-01-03, 公開日: 2018-11-28, 最終更新日: 2019-03-27)

• 主引用文献: Richter, H.,Satz, A.L.,Bedoucha, M.,Buettelmann, B.,Petersen, A.C.,Harmeier, A.,Hermosilla, R.,Hochstrasser, R.,Burger, D.,Gsell, B.,Gasser, R.,Huber, S.,Hug, M.N.,Kocer, B.,Kuhn, B.,Ritter, M.,Rudolph, M.G.,Weibel, F.,Molina-David, J.,Kim, J.J.,Santos, J.V.,Stihle, M.,Georges, G.J.,Bonfil, R.D.,Fridman, R.,Uhles, S.,Moll, S.,Faul, C.,Fornoni, A.,Prunotto, M.; DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.; Acs Chem.Biol., 14:37-49, 2019; PubMed: 30452219; DOI: 10.1021/acschembio.8b00866

実験手法

X-RAY DIFFRACTION (2.87 Å)