6FEL

Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511

6FEL の概要

• エントリーDOI: 10.2210/pdb6fel/pdb
• 分子名称: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 (3 entities in total)
• 機能のキーワード: 14-3-3 protein, calcium/calmodulin-dependent protein kinase kinase 2, camkk2, phosphorylation, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 112325.90

構造登録者

Lentini Santo, D.,Obsilova, V.,Obsil, T. (登録日: 2018-01-02, 公開日: 2018-01-10, 最終更新日: 2024-10-09)

主引用文献

Psenakova, K.,Petrvalska, O.,Kylarova, S.,Lentini Santo, D.,Kalabova, D.,Herman, P.,Obsilova, V.,Obsil, T.
14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
Biochim. Biophys. Acta, 1862:1612-1625, 2018

PubMed Abstract: Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a member of the Ca/calmodulin-dependent kinase (CaMK) family involved in adiposity regulation, glucose homeostasis and cancer. This upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase is inhibited by phosphorylation, which also triggers an association with the scaffolding protein 14-3-3. However, the role of 14-3-3 in the regulation of CaMKK2 remains unknown.

PubMed: 29649512
DOI: 10.1016/j.bbagen.2018.04.006

実験手法

X-RAY DIFFRACTION (2.84 Å)