6FD4

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 hours post crystallization

Summary for 6FD4

Entry DOI	10.2210/pdb6fd4/pdb
Related	6FCH 6FCI 6FCL 6FD5 6FD6
Descriptor	Adenine phosphoribosyltransferase, MAGNESIUM ION, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ... (4 entities in total)
Functional Keywords	rossman fold, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	39651.66
Authors	Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2017-12-21, release date: 2018-08-15, Last modification date: 2024-01-17)
Primary citation	Huyet, J.,Ozeir, M.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol, 25:666-676.e4, 2018 Cited by PubMed: 29576532 DOI: 10.1016/j.chembiol.2018.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation