6FD2

Radical SAM 1,2-diol dehydratase AprD4 in complex with its substrate paromamine

Summary for 6FD2

• Entry DOI: 10.2210/pdb6fd2/pdb
• Descriptor: Putative apramycin biosynthetic oxidoreductase 4, paromamine, IRON/SULFUR CLUSTER, ... (6 entities in total)
• Functional Keywords: radical sam, fes-cluster containing enzyme, 1, 2-diol dehydratase, biosynthetic protein
• Biological source: Streptoalloteichus tenebrarius (strain ATCC 17920 / DSM 40477 / NCIB 11028) (Streptomyces tenebrarius)
• Total number of polymer chains: 2
• Total formula weight: 102915.54

Authors

Liu, W.Q.,Amara, P.,Mouesca, J.M.,Ji, X.,Renoux, O.,Martin, L.,Zhang, C.,Zhang, Q.,Nicolet, Y. (deposition date: 2017-12-21, release date: 2018-01-17, Last modification date: 2024-01-17)

• Primary citation: Liu, W.Q.,Amara, P.,Mouesca, J.M.,Ji, X.,Renoux, O.,Martin, L.,Zhang, C.,Zhang, Q.,Nicolet, Y.; 1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility.; J. Am. Chem. Soc., 140:1365-1371, 2018; PubMed: 29300094; DOI: 10.1021/jacs.7b10501

Experimental method

X-RAY DIFFRACTION (2.55 Å)