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6FCX

Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)

Summary for 6FCX
Entry DOI10.2210/pdb6fcx/pdb
DescriptorMethylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
Functional Keywordsone carbon metabolism, rossmann fold, s-adenosyl-methionine, structural genomics, structural genomics consortium, sgc, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight143826.15
Authors
Primary citationFroese, D.S.,Kopec, J.,Rembeza, E.,Bezerra, G.A.,Oberholzer, A.E.,Suormala, T.,Lutz, S.,Chalk, R.,Borkowska, O.,Baumgartner, M.R.,Yue, W.W.
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Nat Commun, 9:2261-2261, 2018
Cited by
PubMed: 29891918
DOI: 10.1038/s41467-018-04735-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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