6FCX

Structure of human 5,10-methylenetetrahydrofolate reductase (MTHFR)

6FCX の概要

• エントリーDOI: 10.2210/pdb6fcx/pdb
• 分子名称: Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: one carbon metabolism, rossmann fold, s-adenosyl-methionine, structural genomics, structural genomics consortium, sgc, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 143826.15

構造登録者

Kopec, J.,Bezerra, G.A.,Oberholzer, A.E.,Rembeza, E.,Sorrell, F.J.,Chalk, R.,Borkowska, O.,Ellis, K.,Kupinska, K.,Krojer, T.,Burgess-Brown, N.,Von Delft, F.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Froese, D.S.,Baumgartner, M.,Yue, W.W.,Structural Genomics Consortium (SGC) (登録日: 2017-12-21, 公開日: 2018-05-16, 最終更新日: 2018-07-04)

• 主引用文献: Froese, D.S.,Kopec, J.,Rembeza, E.,Bezerra, G.A.,Oberholzer, A.E.,Suormala, T.,Lutz, S.,Chalk, R.,Borkowska, O.,Baumgartner, M.R.,Yue, W.W.; Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.; Nat Commun, 9:2261-2261, 2018; PubMed: 29891918; DOI: 10.1038/s41467-018-04735-2

実験手法

X-RAY DIFFRACTION (2.5 Å)