6FCF

CHK1 KINASE IN COMPLEX WITH COMPOUND 44

Summary for 6FCF

Entry DOI	10.2210/pdb6fcf/pdb
Descriptor	Serine/threonine-protein kinase Chk1, 4-[[(2~{R},3~{S})-2-methylpiperidin-3-yl]amino]-2-phenyl-thieno[3,2-c]pyridine-7-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, chk1, kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	32367.41
Authors	Read, J.A.,Breed, J. (deposition date: 2017-12-20, release date: 2018-01-17, Last modification date: 2018-02-21)
Primary citation	Yang, B.,Vasbinder, M.M.,Hird, A.W.,Su, Q.,Wang, H.,Yu, Y.,Toader, D.,Lyne, P.D.,Read, J.A.,Breed, J.,Ioannidis, S.,Deng, C.,Grondine, M.,DeGrace, N.,Whitston, D.,Brassil, P.,Janetka, J.W. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J. Med. Chem., 61:1061-1073, 2018 Cited by PubMed: 29301085 DOI: 10.1021/acs.jmedchem.7b01490 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation