6FBV

Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin

6FBV の概要

• エントリーDOI: 10.2210/pdb6fbv/pdb
• EMDBエントリー: 4230
• 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (9 entities in total)
• 機能のキーワード: lipiarmycin, rna pol, rnap, inhibitor, drug, clostridium difficile, antibiotic, tiacumicin b, ccdc 114782, transcription
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 423419.92

構造登録者

Das, K.,Lin, W.,Ebright, E. (登録日: 2017-12-19, 公開日: 2018-02-28, 最終更新日: 2024-05-15)

• 主引用文献: Lin, W.,Das, K.,Degen, D.,Mazumder, A.,Duchi, D.,Wang, D.,Ebright, Y.W.,Ebright, R.Y.,Sineva, E.,Gigliotti, M.,Srivastava, A.,Mandal, S.,Jiang, Y.,Liu, Y.,Yin, R.,Zhang, Z.,Eng, E.T.,Thomas, D.,Donadio, S.,Zhang, H.,Zhang, C.,Kapanidis, A.N.,Ebright, R.H.; Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).; Mol. Cell, 70:60-71.e15, 2018; PubMed: 29606590; DOI: 10.1016/j.molcel.2018.02.026

実験手法

ELECTRON MICROSCOPY (3.52 Å)